Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiation
نویسندگان
چکیده
منابع مشابه
Lineage specification in the mouse preimplantation embryo.
During mouse preimplantation embryo development, totipotent blastomeres generate the first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm. In recent years, studies have shown that this process appears to be regulated by differences in cell-cell interactions, gene expression and the microenvironment of individual cells, rather than the active partitioning of ma...
متن کاملDownregulation of Par3 and aPKC function directs cells towards the ICM in the preimplantation mouse embryo.
Generation of inside cells that develop into inner cell mass (ICM) and outside cells that develop into trophectoderm is central to the development of the early mouse embryo. Critical to this decision is the development of cell polarity and the associated asymmetric (differentiative) divisions of the 8-cell-stage blastomeres. The underlying molecular mechanisms for these events are not understoo...
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Cell lineage studies in mollusk embryos have documented numerous variations on the lophotrochozoan theme of spiral cleavage. In the experimentally tractable embryo of the mud snail Ilyanassa, cell lineage has previously been described only up to the 29-cell stage. Here I provide a chronology of cell divisions in Ilyanassa to the stage of 84 cells (about 16 hours after first cleavage at 23 degre...
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Preimplantation development of the mammalian embryo consists of stages that include formation of the <span style="font-variant: normal; font-style: normal; font-family: ArialM...
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Environmental conditions during early mammalian embryo development are critical and some adaptational phenomena are observed. However, the mechanisms underlying them remain largely masked. Previously, we reported that AQP5 expression is modified by the environmental condition without losing the developmental potency. In this study, AQP11 was examined instead. To compare expression pattern betwe...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2013
ISSN: 0890-9369
DOI: 10.1101/gad.219618.113